Our research group’s area of study encompasses selected aspects of food chemistry, food toxicology, and general toxicology. We focus specifically on the influence of various exposures on genomic stability, taking into account DNA damage, DNA repair processes, epigenetics, and redox regulation. The primary focus is on toxic and carcinogenic metal compounds, including metal-based nanomaterials, and essential trace elements, as well as their interactions. In this context, investigations into molecular mechanisms of action are combined with current risk assessment concepts. In the case of trace elements, both positive and adverse effects, depending on the dose, are considered as the basis for a risk-benefit assessment, including with regard to dietary supplements.

The outcomes of basic molecular research and risk assessment contribute directly to practical occupational and consumer protection. They are incorporated through Prof. Dr. Hartwig’s chairmanship or participation in relevant scientific bodies, in particular as chair of the “ Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area of the DFG (MAK Commission), as a former member of the European “Scientific Committee on Occupational Exposure Limits” (SCOEL) and as a co-opted member of the “Risk Assessment Committee” (RAC) of the European Chemicals Agency (ECHA).

• Influence of metal compounds on cellular epigenetic mechanisms
• Influence of metal compounds and trace elements on the cellular proteome as well as the redox regulation 
• New platinating DNA-damaging agents
   

Finished BMBF- and DFG-funded projects