Academic Training

1996                   Habilitation

                           University of Bremen, Biochemistry

1987                   Ph.D.

                           University of Bremen

1984                   Diploma, Chemistry

                           University of Bremen

1977 - 1984        Study of Chemistry

                           University of Bremen

Scientific Career

since 2010          Full Professor (Food Chemistry and Toxicology), Karlsruhe Institute of Technology (KIT)

2004 - 2010        Full Professor (Food Chemistry), Technical University Berlin

1998 - 2004        University Professor (Food Chemistry), University of Karlsruhe

1988 - 1998        Scientific Assistant, University of Bremen

1986                   Research stay at the "Institute of Environmental Medicine",
                           Sterling Forest, New York, in the laboratory of Prof. Rossman

Main Research Areas

• Impact of carcinogenic metal compounds, metal-based nanoparticles, essential trace elements and bioactive food ingredients on the stability of the genome:
   
  • DNA damage
  • Interactions with the cellular response to DNA damage (DNA repair systems, cell cycle control and tumor suppressor functions)
  • Interactions with the redox regulation of signalling pathways
     
• Interactions between toxic and essential metal ions
   
• Oxidative stress

Offers, Honours, Awards and Special Recognitions (selection)

2018                   Toxicology Award of the Society of Toxicology (GT)

2009                   Offer of a Full Professorship "Nutritional Toxicology" at the University of Potsdam (declined)

2008                   Innovation Award 2008 of the "Deutsche Gesellschaft für Arbeits- und
                           Umweltmedizin e.V." (DGAUM), for the development of concepts for occupational
                           exposure limit settings

2008                   Nomination as Chair of the "Permanent Senate Commission for the Investigation of Health
                           Hazards of Chemical Compounds in the Work Area" (MAK-Commission)

2006                   Award of the "Gesellschaft für Umwelt-Mutationsforschung" (GUM)

Membership in Scientific Committees

since 2018           Member of the Central Committee on Biological Safety (ZKBS) in Germany

since 2007           Chair of the "Permanent Senate Commission for the Investigation of Health Hazards of
                            Chemical Compunds in the Work Area" (MAK-Commission)

2010 - 2014         Chair of the German Society for DNA Repair (DGDR)

since 2007           Member of the "Scientific Committee on Occupational Exposure Limits" (SCOEL)

2010 - 2013         Member of the "Human biomonitoring commission" of the Federal Office for Environment, Germany

2007 - 2012         Member of the Scienitific Advisory Board of the Federal Institute for
                            Risk Assessment (BfR), Germany

2010 - 2011         Expert for the European Food Safety Authority (EFSA)

since 2004           Member of several working groups of the "International Agency for Research on Cancer " (IARC)

Selected Publications

• Piberger A. L., Krüger C., Strauch B. M., Schneider B., Hartwig A. (2018) BPDE-induced genotoxicity: relationship between DNA adducts, mutagenicity in the in vitro PIG-A assay, and the transcriptional response to DNA damage in TK6 cells. Arch Toxicol. 92, 541-551.

• Strauch B.M., Niemand R.K., Winkelbeiner N.L., Hartwig A. (2017) Comparison between micro- and nanosized copper oxide and water soluble copper chloride: interrelationship between intracellular copper concentrations, oxidative stress and DNA damage response in human lung cells. Part Fibre Toxicol. 14:28.
   

• Fischer BM, Neumann D, Piberger AL, Risnes SF, Köberle B, Hartwig A (2016) Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium. Arch Toxicol. 90, 2745 - 2761.
   

• Krüger CT, Hofmann M, Hartwig A (2015) The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells. Arch Toxicol. 89, 2429-2443.
   

• Hartwig, A (2013) Metal interaction with redox regulation: An integrating concept in metal carcinogenesis? Free Radical Biology and Medicine, 55, 63 – 72.
   

• Beyersmann D and Hartwig A (2008) Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Arch Toxicol, 82, 493 – 512.
   

• Hartwig A, Pelzer A, Asmuss M and Bürkle A (2003) Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells. Int J Cancer, 104, 1 – 6.
   

• Hartwig A (2001) Zinc finger proteins as potential targets for toxic metal ions: Differential effects on structure and function. Antioxid Redox Signaling, 3, 625 – 634.