Alexandra Friesen

Alexandra Friesen

Research focus

  •  Pulmonary exposure of microscale materials

    • exposure scenarios via air-liquid interface (ALI)

    • assessment of pulmonary toxicity depending on cell culture models and materials forms

  • Toxicological investigations of carbon fibres and α-quartz particles

    • investigation of cytotoxicity and genotoxicity

    • investigation of inflammatory and fibrotic potential


  • Generation of gene expression profiles by high-throughput RT-qPCR

  • Detection of DNA strand breaks (alkaline unwinding)

  • Cytotoxicity assays

  • Air-liquid interface cell culture


  • Supervision of Master and Bachelor theses
  • Supervision of the research-teaching lab biochemistry and toxicology


Hufnagel M., Neuberger R., Wall J., Link M., Friesen A., Hartwig A.
Impact of Differentiated Macrophage-Like Cells on the Transcriptional Toxicity Profile of CuO Nanoparticles in Co-Cultured Lung Epithelial Cells
International Journal of Molecular Sciences (2021)