Copper toxicity (team proteomics)

• Toxicological characterization of copper compounds with a focus on proteomics and transcriptomics 

• Impact of copper compounds on the cellular redox regulation in vitro (Copper oxide nanoparticles and water soluble copper compounds)

• Correlation of data between gene expression and posttranslational protein modification with respect to copper exposure in vitro 

Methods

• Cell culture
• Cytotoxicity studies 
• Western Blot
• Carbonyl Assay
• LC-MS/MS (Orbitrap) - Proteomics 
• High-throughput RT-qPCR
• Live cell imaging