TL

Tatjana Lumpp

Research focus

Epigenetic influence of carcinogenic metal compounds on DNA repair genes considering post-translational histone modifications

  • Investigation of metal-induced chromatin changes with regard to chromatin accesibillity as well as global and gene-specific histone modification patterns

  • Gene expression analysis

  • Cytotoxicity studies
 
 

Methods

  • Gene-specific analysis of histone modifications by ChIP-qPCR

  • Gene expression profiling using high-throughput RT-qPCR

  • Cytotoxicity assays

  • Quantification of metals using AAS

  • Protein analysis via immunoblot

  • Immunofluorescence experiments

Teaching

  • Supervision of master thesis, term papers and bachelor thesis

  • Supervision of teaching lab "Toxikologisches Praktikum" (AAS & Electrophoresis)

 

Publications

Fischer, F.; Stößer, S.; Wegmann, L.; Veh, E.; Lumpp, T.; Parsdorfer, M.; Schumacher, P.; Hartwig, A. Chromate Affects Gene Expression and DNA Methylation in Long-Term In Vitro Experiments in A549 Cells. https://doi.org/10.3390/ijms251810129 (2024)

Lumpp, T.; Stösser, S.; Fischer, F.; Hartwig, A.; Koberle, B. Role of Epigenetics for the Efficacy of Cisplatin. International Journal of Molecular Sciences 2024

Stösser, S.; Lumpp, T.; Fischer, F.; Gunesch, S.; Schumacher, P.; Hartwig, A. Effect of Long-Term Low-Dose Arsenic Exposure on DNA Methylation and Gene Expression in Human Liver Cells. International Journal of Molecular Sciences 2023