Publikationen
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Rose F., Köberle B., Honnen S., Bay C., Burhenne J., Weiss K., Haefeli W.E., Theile D.:
RNA is a pro-apoptotic target of cisplatin in cancer cell lines and C. elegans.
Biomed Pharmacol (2024), DOI:10.1016/j.biopha.2024.116450
Köberle B., Usanova S., Piee-Staffa A., Heinicke U., Clauss F., Brozovic A., Kaina B.:
Strong apoptotic response of testis tumor cells following cisplatin treatment.
Int Urol Nephrol (2024), DOI:10.1007/s11255-023-03825-5
Lumpp T., Stößer S., Fischer F., Hartwig A., Köberle B.:
Role of Epigenetics for the Efficacy of Cisplatin.
Stahlberger M., Steinlein O., Adam C. R., Rotter M., Hohmann J., Nieger M., Köberle B., Bräse S.
Fluorescent annulated imidazo[4,5-c]isoquinolines via a GBB-3CR/imidoylation sequence – DNA-interactions in pUC-19 gel electrophoresis mobility shift assay.
Schoch S., Sen V., Brenner W., Hartwig A., Köberle B.
In Vitro Nephrotoxicity Studies of Established and Experimental-Based Compounds.
Biomedicines (2021)
In Vitro Nephrotoxicity Studies of Established and Experimental-Based Compounds.
Biomedicines (2021)
Köberle B., Schoch S.
Platinum Complexes in Colorectal Cancer and Other Solid Tumors.
Cancers (2021)
Platinum Complexes in Colorectal Cancer and Other Solid Tumors.
Cancers (2021)
Schoch S., Gajewski S., Rothfuß J., Hartwig A., Köberle B.
Comparative Study of the Mode of Action of Clinically Approved Platinum-Based Chemotherapeutics.
International Journal of Molecular Sciences (2020)
Comparative Study of the Mode of Action of Clinically Approved Platinum-Based Chemotherapeutics.
International Journal of Molecular Sciences (2020)
Schoch S., Sen V., Gajewski S., Golubev V., Strauch B., Hartwig A., Köberle B.
Acitivity profile of the cisplatin analogue PN149 in different tumor cell.
Biochemical Pharmacology (2018)
Acitivity profile of the cisplatin analogue PN149 in different tumor cell.
Biochemical Pharmacology (2018)
Cetraz M., Sen V., Schoch S., Streule, K., Golubev V., Hartwig A., Köberle B.
Platinum(IV)-nitroxyl complexes as possible candidates to circumvent cisplatin resistance in RT112 bladder cancer cells.
Archives of Toxicology (2017)
Platinum(IV)-nitroxyl complexes as possible candidates to circumvent cisplatin resistance in RT112 bladder cancer cells.
Archives of Toxicology (2017)
Bestgen S., Seidl C., Wiesner T., Zimmer A., Falk M., Köberle B., Austeri M., Paradies J., Bräse S., Schepers U., Roesky P.W.:
Double-Strand DNA Breaks Induced by Paracyclophane Gold(I) Complexes.
Chemistry (2017) DOI:10.1002/chem.201605237
Double-Strand DNA Breaks Induced by Paracyclophane Gold(I) Complexes.
Chemistry (2017) DOI:10.1002/chem.201605237
Köberle B., Koch B., Fischer B.M., Hartwig A.
Single nucleotide polymorphisms in DNA repair genes and putative cancer risk.
Archives of Toxicology (2016)
Single nucleotide polymorphisms in DNA repair genes and putative cancer risk.
Archives of Toxicology (2016)
Fleck S.C., Sauter F., Pfeiffer E., Metzler M., Hartwig A., Köberle B.
DNA damage and repair kinetics of the Alternaria mycotoxins alternariol, altertoxin II and stemphylotoxin III in cultured cells.
Mutation Research (2016)
DNA damage and repair kinetics of the Alternaria mycotoxins alternariol, altertoxin II and stemphylotoxin III in cultured cells.
Mutation Research (2016)
Fischer B.M., Neumann D., Piberger A.L., Risnes S.F., Köberle B., Hartwig A.:
Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium.
Arch Toxicol (2016) DOI:10.1007/s00204-015-1621-7
Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium.
Arch Toxicol (2016) DOI:10.1007/s00204-015-1621-7
Piberger A.L., Köberle B., Hartwig A.:
The broccoli-born isothiocyanate sulforaphane impairs nucleotide excision repair: XPA as one potential target.
Arch Toxicol (2014) DOI:10.1007/s00204-013-1178-2
The broccoli-born isothiocyanate sulforaphane impairs nucleotide excision repair: XPA as one potential target.
Arch Toxicol (2014) DOI:10.1007/s00204-013-1178-2
Hartwig A., Köberle B., Michalke B.
Nutzen-Risiko-Bewertung von Mineralstoffen und Spurenelementen: Biochemische, physiologische und toxikologische Aspekte.
KIT-Verlag, Karlsruhe (2014)
Nutzen-Risiko-Bewertung von Mineralstoffen und Spurenelementen: Biochemische, physiologische und toxikologische Aspekte.
KIT-Verlag, Karlsruhe (2014)
Brozovic A., Vuković L., Stupin Polančac D., Arany I., Köberle B., Fritz G., Fiket Ž., Majhen D., Ambriović-Ristov A., Osmak M.
Endoplasmic reticulum stress is involved in the response of human laryngeal carcinoma cells to Carboplatin but is absent in Carboplatin-resistant cells
PLoS One (2013)
Albers A.E., Chen C., Köberle B., Qian X., Klussmann J.P., Wollenberg B., Kaufmann A.M.
Stem cells in squamous head and neck cancer.
Critical reviews in oncology/hematology (2012)
Helbig L., Damrot H., Hülsenbeck J., Köberle B., Brozovic A., Osmak M., Fiket Z., Kaina B., Fritz G.:
Late activation of stress-activated protein kinases/c-JunN-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells.
J Biol Chem (2011), DOI:10.1074/jbc.M110.190645
Köberle B., Tomicic M., Usanova S., Kaina B.
Cisplatin resistance: Preclinical findings and clinical implications.
Biochimica et Biophysica Acta - Reviews on Cancer (2010)Usanova S., Piee-Staffa A., Sied U., Thomale J., Schreiber A., Kaina B., Köberle B.
Cisplatin sensitivity of testis tumor cells is due to dericiency in interstrand-crosslink repair and low ERCC1-XPF expression.
Mol Cancer (2010)
Köberle B., Ditz C., Kausch I., Wollenberg B., Ferris R.L., Albers A.
Metastases of squamous cell carcinoma of the head and neck show increased levels of nucleotide excision repair protein XPF in vivo that correlate with increased chemoresistance ex vivo.
Chen C., Köberle B., Kaufmann AM, Albers A.
A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment.
Cancers (2010)
Köberle B., Brenner W., Albers A., Usanova S., Thüroff J.W., Kaina B.:
ERCC1 and XPF expression in human testicular germ cell tumors.
Oncol Rep (2010), DOI.org/10.3892/or_00000627
Köberle B., Roginskaya V., Zima K.S., Masters J.R., Wood R.D.
Elevation of XPA protein level in testis tumor cells without increasing resistance to cisplatin or UV irradiation.
Mol Carcinogenesis 47, 580-586 (2008)
Köberle B., Roginskaya V., Wood R.D.
XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells.
DNA Repair 5, 641-648 (2006)
Cummings M., Higginbottom K., McGurk C.J., Gee-Wang O., Köberle B., Oliver R.T.D., Masters J-R.:
XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair.
Biomed Pharmacol (2006), DOI:10.1016/j.bcp.2006.04.025
McGurk C.J.., Cummings M., Köberle B., Hartley J.A., Oliver R.T., Masters J.R., Weiss K., Haefeli W.E., Theile D.:
Regulation of DNA repair gene expression in human cancer cell lines.
J Cell Biochem (2006), DOI:10.1002/jcb.20711
Köberle B., Wittschieben J.P., Wood R.D.
DNA repair and cancer.
Chapter 4 - Cellular and Molecular Biology of Cancer, 4th Edition, Oxford University Press (2005)
Welsh C., Day R., McGurk C., Masters J.R.W., Wood R.D., Köberle B.
Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.
Masters J.R.W., Köberle B.
Curing metastatic cancer: lessons from testicular germ-cell tumours.
Nature reviews. Cancer (2003)
Stoop H., van Gurp R., de Krijger R., Geurts van Kessel A., Köberle B., Oosterhuis W., Looijenga L.:
Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications.
Lab Invest (2001), DOI:10.1038/labinvest.3780302
Wood R.D., Araújo S.J., Batty D.P., Biggerstaff M., Evans E., Gaillard P.-H., Gunz D., Köberle B., Kuraoka I., Moggs J.G., Sandall J.K., Shivji M.K.K.
DNA damage recognition and nucleotide excision repair in mammalian cells.
Köberle B., Masters J.R.W., Hartley J.A., Wood R.D.
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.
Current biology (1999)
Köberle B., Grimaldi K.A., Sunters A., Hartley J.A., Kelland L.R., Masters J.R.W.
DNA repair capacity and cisplatin sensitivity of human testis tumour cells.
Köberle B., Payne J., Grimaldi K.A., Hartley J.A., Kelland L.R., Masters J.R.W.
DNA Repair in Cisplatin-Sensitive and Resistant Human Cell Lines Measured in Specific Genes by Quantitative Polymerase Chain Reaction.
Biochemical Pharmacology (1996)
Pera M.F., Köberle B.. Masters J.R.W.
Exceptional sensitivity of testicular germ cell tumour cell lines to the new anti-cancer agent, temozolomide.
British Journal of Cancer (1995)
Köberle B., Röscheisen C., Helbig R. and Speit G.
Molecular characterization of methyl methanesulphonate (MMS)-induced HPRT mutations in V79 cells.
Mutation Research (1993)
Köberle B., Speit G.
Molecular characterization of mutations at the hprt locus in V79 Chinese hamster cells induced by bleomycin in the presence of inhibitors of DNA repair.
Mutation Research (1991)
Köberle B., Haupter S., Just W. Speit G.
Mutation screening of bleomycin-induced V79 Chinese hamster hprt mutants using multiplex polymerase chain reaction.
Mutagenesis (1991)
Köberle B., Speit G.
The effect of glutathione depletion on sister-chromatid exchange induction by cytostatic drugs.
Mutation Research (1990)
Speit G., Garkov S., Haupter S.. Köberle B.
Genetic effects of 2-aminopurine in mammalian cells.
Mutagenesis (1990)