2026-2021

Schwarz, M.; Epe, B.; Wohak, L.E.; Voss, C.; Hartwig, A. The role of cytotoxicity in the process of carcinogenesis. Archives of Toxicology 2026, 100, 3791-3799, doi:10.1007/s00204-026-04408-w.

Michaelsen, S.; Laube, B.; Bartsch, R.; Baumgärtel, S.; Breuer, D.; Grebenstein, R.; Leibold, E.; Lohmann, R.; Merk, H.; Schleh, C.; Fartasch, M.; Bader, M.; Drexler, H.; Blömeke, B.; Hartwig, A. Scientific approach to derive occupational exposure limits for formaldehyde releasers. Archives of Toxicology 2026, 10.1007/s00204-026-04489-7, doi:10.1007/s00204-026-04489-7.

Lumpp, T.; Hijazi, H.; Stößer, S.; Tekin, E.; Brunner, L.; Fischer, F.; Brugière, S.; Pflieger, D.; Hartwig, A. Impact of Arsenite on Transient and Persistent Histone H3 Modifications and Transcriptional Response. Chemical Research in Toxicology 2026, 39, 64-78, doi:10.1021/acs.chemrestox.5c00312.

Link, M.; Kuhn, J.; Parsdorfer, M.; Hartwig, A. Distinct Interactions of Arsenite and Cadmium with Metal Homeostasis and the Cellular Stress Response in Human Bronchial Epithelial Cells. Int J Mol Sci 2026, 27, doi:10.3390/ijms27177809.

Kuhn, J.; Gliga, A.R.; Aissouni, C.I.; Glowacki, A.M.; Parsdorfer, M.; Link, M.; Karlsson, H.L.; Hartwig, A. Transcriptomic Profiling of Toxic Copper Overload Induced by CuO Nanoparticles or Copper Ions in Human Lung Epithelial and Liver Cells. Nanomaterials 2026, 16, doi:10.3390/nano16100590.

Hebisch, R.; Göen, T.; Hartwig, A. New measurement methods for workplace measurements and biomonitoring. Gefahrstoffe Reinhaltung der Luft 2026, 86, 65-69, doi:10.37544/0949-8036-2026-03-04-65.

Hartwig, A.; Hartig, K. 70 years of the MAK Commission: Acceptance thanks to transparency. Gefahrstoffe Reinhaltung der Luft 2026, 86, 37.

Yan, J.; Takamiya, M.; Zhang, D.; Pace, G.; Rastegar, S.; Wang, H.; Schoch, S.; Köberle, B.; Hartwig, A.; Dickmeis, T.; Weiss, C. Zebrafish as a model organism in One Health Toxicology: Impact of solvents and exposure routes on the toxicity of platinum anticancer drugs. Environment International 2025, 197, doi:10.1016/j.envint.2025.109349.

Weistenhöfer, W.; Göen, T.; Drexler, H.; Hartwig, A. What requirements should suitable human biomonitoring parameters meet? Arbeitsmedizin Sozialmedizin Umweltmedizin 2024, 2024, 94, doi:10.17147/asu-1-336765.

Lumpp, T.; Stößer, S.; Fischer, F.; Hartwig, A.; Köberle, B. Role of Epigenetics for the Efficacy of Cisplatin. International Journal of Molecular Sciences 2024, 25, doi:10.3390/ijms25021130.

Fischer, F.; Stößer, S.; Wegmann, L.; Veh, E.; Lumpp, T.; Parsdorfer, M.; Schumacher, P.; Hartwig, A. Chromate Affects Gene Expression and DNA Methylation in Long-Term In Vitro Experiments in A549 Cells. International Journal of Molecular Sciences 2024, 25, doi:10.3390/ijms251810129.

Stößer, S.; Lumpp, T.; Fischer, F.; Gunesch, S.; Schumacher, P.; Hartwig, A. Effect of Long-Term Low-Dose Arsenic Exposure on DNA Methylation and Gene Expression in Human Liver Cells. International Journal of Molecular Sciences 2023, 24, doi:10.3390/ijms242015238.

Melenbacher, A.; Heinlein, L.; Hartwig, A.; Stillman, M.J. 63Cu(I) binding to human kidney 68Zn7-βα MT1A: Determination of Cu(I)-thiolate cluster domain specificity from ESI-MS and room temperature phosphorescence spectroscopy. Metallomics 2023, 15, doi:10.1093/mtomcs/mfac101.

Matthäus, T.; Stößer, S.; Seren, H.Y.; Haberland, V.M.M.; Hartwig, A. Arsenite Impairs BRCA1-Dependent DNA Double-Strand Break Repair, a Mechanism Potentially Contributing to Genomic Instability. International Journal of Molecular Sciences 2023, 24, doi:10.3390/ijms241814395.

Hartwig, A.; van Thriel, C. Risk Assessment of Nanomaterials Toxicity. Nanomaterials 2023, 13, doi:10.3390/nano13091512.

Haberland, V.M.M.; Magin, S.; Iliakis, G.; Hartwig, A. Impact of Manganese and Chromate on Specific DNA Double-Strand Break Repair Pathways. International Journal of Molecular Sciences 2023, 24, doi:10.3390/ijms241210392.

Friesen, A.; Fritsch-Decker, S.; Mülhopt, S.; Quarz, C.; Mahl, J.; Baumann, W.; Hauser, M.; Wexler, M.; Schlager, C.; Gutmann, B.; Krebs, T.; Goßmann, A.K.; Weis, F.; Hufnagel, M.; Stapf, D.; Hartwig, A.; Weiss, C. Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers. International Journal of Molecular Sciences 2023, 24, doi:10.3390/ijms24031927.

Dilger, M.; Armant, O.; Ramme, L.; Mülhopt, S.; Sapcariu, S.C.; Schlager, C.; Dilger, E.; Reda, A.; Orasche, J.; Schnelle-Kreis, J.; Conlon, T.M.; Yildirim, A.Ö.; Hartwig, A.; Zimmermann, R.; Hiller, K.; Diabaté, S.; Paur, H.R.; Weiss, C. Systems toxicology of complex wood combustion aerosol reveals gaseous carbonyl compounds as critical constituents. Environment International 2023, 179, doi:10.1016/j.envint.2023.108169.

Caipa Garcia, A.L.; Kucab, J.E.; Al-Serori, H.; Beck, R.S.S.; Fischer, F.; Hufnagel, M.; Hartwig, A.; Floeder, A.; Balbo, S.; Francies, H.; Garnett, M.; Huch, M.; Drost, J.; Zilbauer, M.; Arlt, V.M.; Phillips, D.H. Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures. International Journal of Molecular Sciences 2023, 24, doi:10.3390/ijms24010606.

Wall, J.; Seleci, D.A.; Schworm, F.; Neuberger, R.; Link, M.; Hufnagel, M.; Schumacher, P.; Schulz, F.; Heinrich, U.; Wohlleben, W.; Hartwig, A. Comparison of metal-based nanoparticles and nanowires: Solubility, reactivity, bioavailability and cellular toxicity. Nanomaterials 2022, 12, doi:10.3390/nano12010147.

Tschiche, H.R.; Bierkandt, F.S.; Creutzenberg, O.; Fessard, V.; Franz, R.; Greiner, R.; Gruber-Traub, C.; Haas, K.H.; Haase, A.; Hartwig, A.; Hesse, B.; Hund-Rinke, K.; Iden, P.; Kromer, C.; Loeschner, K.; Mutz, D.; Rakow, A.; Rasmussen, K.; Rauscher, H.; Richter, H.; Schoon, J.; Schmid, O.; Som, C.; Spindler, L.M.; Tovar, G.E.M.; Westerhoff, P.; Wohlleben, W.; Luch, A.; Laux, P. Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities. NanoImpact 2022, 28, doi:10.1016/j.impact.2022.100416.

Tschiche, H.R.; Bierkandt, F.S.; Creutzenberg, O.; Fessard, V.; Franz, R.; Giese, B.; Greiner, R.; Haas, K.H.; Haase, A.; Hartwig, A.; Hund‑Rinke, K.; Iden, P.; Kromer, C.; Loeschner, K.; Mutz, D.; Rakow, A.; Rasmussen, K.; Rauscher, H.; Richter, H.; Schoon, J.; Schmid, O.; Som, C.; M.Tovar, G.E.; Westerhoff, P.; Wohlleben, W.; Luch, A.; Laux, P. Environmental considerations and current status of grouping and regulation of engineered nanomaterials. Environmental Nanotechnology, Monitoring and Management 2022, 18, doi:10.1016/j.enmm.2022.100707.

Schumacher, P.; Fischer, F.; Sann, J.; Walter, D.; Hartwig, A. Impact of Nano-and Micro-Sized Chromium(III) Particles on Cytotoxicity and Gene Expression Profiles Related to Genomic Stability in Human Keratinocytes and Alveolar Epithelial Cells. Nanomaterials 2022, 12, doi:10.3390/nano12081294.

Rietjens, I.M.C.M.; Michael, A.; Bolt, H.M.; Siméon, B.; Andrea, H.; Nils, H.; Christine, K.; Angela, M.; Gloria, P.; Daniel, R.; Natalie, T.; Gerhard, E. The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment. Archives of Toxicology 2022, 96, 1297-1352, doi:10.1007/s00204-022-03242-0.

Karlsson, H.L.; Hartwig, A. Lung Cell Toxicity of Metal-Containing Nanoparticles. Nanomaterials 2022, 12, doi:10.3390/nano12173044.

Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Weiss, C.; Hartwig, A. Gene Expression Profiling of Mono- and Co-Culture Models of the Respiratory Tract Exposed to Crystalline Quartz under Submerged and Air-Liquid Interface Conditions. International Journal of Molecular Sciences 2022, 23, doi:10.3390/ijms23147773.

Friesen, A.; Fritsch-Decker, S.; Hufnagel, M.; Mülhopt, S.; Stapf, D.; Hartwig, A.; Weiss, C. Comparing α-Quartz-Induced Cytotoxicity and Interleukin-8 Release in Pulmonary Mono-and Co-Cultures Exposed under Submerged and Air-Liquid Interface Conditions. International Journal of Molecular Sciences 2022, 23, doi:10.3390/ijms23126412.

Wedler, N.; Matthäus, T.; Strauch, B.; Dilger, E.; Waterstraat, M.; Mangerich, A.; Hartwig, A. Impact of the Cellular Zinc Status on PARP-1 Activity and Genomic Stability in HeLa S3 Cells. Chemical Research in Toxicology 2021, 34, 839-848, doi:10.1021/acs.chemrestox.0c00452.

Schoch, S.; Sen, V.; Brenner, W.; Hartwig, A.; Köberle, B. In vitro nephrotoxicity studies of established and experimental platinum-based compounds. Biomedicines 2021, 9, doi:10.3390/biomedicines9081033.

Nicolai, M.M.; Witt, B.; Hartwig, A.; Schwerdtle, T.; Bornhorst, J. A fast and reliable method for monitoring genomic instability in the model organism Caenorhabditis elegans. Archives of Toxicology 2021, 95, 3417-3424, doi:10.1007/s00204-021-03144-7.

Hufnagel, M.; Neuberger, R.; Wall, J.; Link, M.; Friesen, A.; Hartwig, A. Impact of differentiated macrophage-like cells on the transcriptional toxicity profile of cuo nanoparticles in co-cultured lung epithelial cells. International Journal of Molecular Sciences 2021, 22, doi:10.3390/ijms22095044.

Hufnagel, M.; May, N.; Wall, J.; Wingert, N.; Garcia-Käufer, M.; Arif, A.; Hübner, C.; Berger, M.; Mülhopt, S.; Baumann, W.; Weis, F.; Krebs, T.; Becker, W.; Gminski, R.; Stapf, D.; Hartwig, A. Impact of nanocomposite combustion aerosols on a549 cells and a 3d airway model. Nanomaterials 2021, 11, doi:10.3390/nano11071685.

Drexler H., Hartwig A. Die neue Arbeitsweise der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher ­Arbeitsstoffe der Deutschen Forschungsgemeinschaft (MAK-Kommission) am Beispiel der ­Grenzwertevaluierung von Blei. ASU Zeitschrift für Medizinische Prävention 2021, 7, doi:10.17147/asu-2107-7928.